Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 3/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2027313 | 0.89 | ABL1 (0.36) | TRPV1PIK3CDABL1NPC1MAPT | |
| SCHEMBL1921392 | 0.87 | TRPV1 (0.35) | TRPV1PIK3CDABL1NPC1MAPT | |
| SCHEMBL302384 | 0.81 | JAK2 (0.39) | TRPV1PIK3CDNPC1MAPTMAPK1 | |
| SCHEMBL1921421 | 0.79 | MKNK1 (0.48) | TRPV1MAPTMKNK1 | |
| SCHEMBL1921947 | 0.78 | AVPR2 (0.32) | TRPV1ABL1 | |
| SCHEMBL302350 | 0.77 | AR (0.36) | TRPV1PIK3CDNPC1MAPTMAPK1 | |
| SCHEMBL12582564 | 0.76 | IRAK4 (0.37) | TRPV1PIK3CDABL1MAPTAR | |
| SCHEMBL1923784 | 0.76 | FAAH (0.41) | ABL1 | |
| SCHEMBL1921986 | 0.76 | MAPK1 (0.36) | TRPV1ABL1NPC1MAPTMAPK1 | |
| SCHEMBL12582587 | 0.74 | TRPV1 (0.35) | TRPV1PIK3CDMAPTARMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500853-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2328871-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2011-06-08 | — | — | EP | claimed |
| WO-2010027746-A2 | HEDGEHOG PATHWAY MODULATORS | IRM LLC (BM) | 2010-03-11 | — | — | WO | claimed |