Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 12/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.37 |
| ▸ | WEE1 | P30291 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699387 | 0.94 | TNK2 (0.56) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL2958057 | 0.89 | TNK2 (0.49) | TNK2SMN1; SMN2CCNKCCNA2CDK2 | |
| SCHEMBL2957631 | 0.74 | TNK2 (0.62) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL2959345 | 0.70 | TNK2 (0.46) | TNK2CDK9CDK6WEE1ALK | |
| SCHEMBL30338434 | 0.66 | TNK2 (0.55) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL2955423 | 0.65 | TNK2 (0.76) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL13239773 | 0.63 | TNK2 (0.81) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL30338625 | 0.63 | TNK2 (1.00) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL30338350 | 0.63 | POLB (0.45) | TNK2BTK | |
| SCHEMBL30338295 | 0.61 | TNK2 (0.42) | TNK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023039548-A1 | KINASE INHIBITORS FOR THE TREATMENT OF PROSTATE CANCER | FRED HUTCHINSON CANCER CENTER (US) | 2023-03-16 | — | — | WO | disclosed |