Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 14/20 | 0.56 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30338396 | 0.94 | TNK2 (0.56) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL2958057 | 0.86 | TNK2 (0.49) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL2957631 | 0.74 | TNK2 (0.62) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL2959345 | 0.70 | TNK2 (0.46) | TNK2WEE1 | |
| SCHEMBL30338434 | 0.66 | TNK2 (0.55) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL2955423 | 0.65 | TNK2 (0.76) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL30338350 | 0.65 | POLB (0.45) | TNK2BTK | |
| SCHEMBL13239773 | 0.63 | TNK2 (0.81) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL30338625 | 0.63 | TNK2 (1.00) | TNK2LCKBTKKDRJAK3 | |
| SCHEMBL30338295 | 0.62 | TNK2 (0.42) | TNK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926734-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS | Amgen Inc. (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007024680-A1 | PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE COMPOUNDS USEFUL AS KINASE ENZYMES MODULATORS | AMGEN INC. (US) | 2007-03-01 | — | — | WO | disclosed |