Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | NEK2 | P51955 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25301419 | 1.00 | RIPK1 (0.41) | RIPK1KDM4EPOLBLMNACYP3A4 | |
| SCHEMBL30338552 | 0.89 | RIPK1 (0.39) | RIPK1KDM4ELMNARXFP1GAA | |
| SCHEMBL25817349 | 0.89 | RIPK1 (0.39) | RIPK1KDM4ELMNARXFP1GAA | |
| SCHEMBL25255422 | 0.87 | RIPK1 (0.42) | RIPK1KDM4EPOLBCYP2C19RXFP1 | |
| SCHEMBL30338981 | 0.87 | RIPK1 (0.42) | RIPK1KDM4EPOLBCYP2C19RXFP1 | |
| SCHEMBL30338869 | 0.86 | RIPK1 (0.42) | RIPK1KDM4EPOLBMAPT | |
| SCHEMBL25817356 | 0.86 | RIPK1 (0.42) | RIPK1KDM4EPOLBMAPT | |
| SCHEMBL31205790 | 0.82 | RIPK1 (0.42) | RIPK1KDM4EPOLB | |
| SCHEMBL25256324 | 0.80 | RIPK1 (0.40) | RIPK1KDM4EPOLBLMNACYP2C19 | |
| SCHEMBL30339402 | 0.80 | RIPK1 (0.40) | RIPK1KDM4EPOLBLMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | claimed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | claimed |
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |