Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | NEK2 | P51955 | 6/20 | 0.44 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | IDH2 | P48735 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25294566 | 1.00 | KDM4E (0.51) | KDM4ECYP2C19USP2HPGDNPSR1 | |
| SCHEMBL30547531 | 0.84 | KDM4E (0.55) | KDM4ECYP2C19USP2HPGDNPSR1 | |
| SCHEMBL25253979 | 0.84 | KDM4E (0.55) | KDM4ECYP2C19USP2HPGDNPSR1 | |
| SCHEMBL20565681 | 0.83 | KDM4E (0.56) | KDM4ECYP2C19USP2HPGDNPSR1 | |
| Hydrochloric Acid SCHEMBL20565233 | 0.82 | KDM4E (0.55) | KDM4ECYP2C19USP2HPGDNPSR1 | |
| Trifluoroacetic Acid SCHEMBL30339273 | 0.82 | KDM4E (0.49) | KDM4ECYP2C19USP2HPGDNPSR1 | |
| SCHEMBL20565611 | 0.81 | KDM4E (0.54) | KDM4ECYP2C19USP2HPGDNPSR1 | |
| SCHEMBL20564608 | 0.79 | KDM4E (0.51) | KDM4ECYP2C19USP2HPGDNPSR1 | |
| SCHEMBL20165678 | 0.78 | RIPK1 (0.67) | — | |
| SCHEMBL20165680 | 0.78 | RIPK1 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |