Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 14/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25303686 | 1.00 | RIPK1 (0.53) | RIPK1PARP1GPBAR1GSK3BDYRK1A | |
| SCHEMBL30338649 | 0.92 | RIPK1 (0.56) | RIPK1GPBAR1DPP4DPP8DPP9 | |
| SCHEMBL25253145 | 0.92 | RIPK1 (0.56) | RIPK1GPBAR1DPP4DPP8DPP9 | |
| SCHEMBL30338527 | 0.90 | RIPK1 (0.49) | RIPK1GSK3BDYRK1ATP53 | |
| SCHEMBL25816910 | 0.90 | RIPK1 (0.49) | RIPK1GSK3BDYRK1ATP53 | |
| SCHEMBL30339421 | 0.89 | RIPK1 (0.53) | RIPK1GPBAR1GSK3BDYRK1ACHRM4 | |
| SCHEMBL25256763 | 0.89 | RIPK1 (0.53) | RIPK1GPBAR1GSK3BDYRK1ACHRM4 | |
| SCHEMBL25817026 | 0.89 | RIPK1 (0.53) | RIPK1GPBAR1GSK3BDYRK1ACHRM4 | |
| SCHEMBL30338913 | 0.89 | RIPK1 (0.53) | RIPK1GPBAR1GSK3BDYRK1ACHRM4 | |
| SCHEMBL25257155 | 0.89 | RIPK1 (0.51) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | claimed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | claimed |
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |