Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 8/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25294541 | 1.00 | RIPK1 (0.46) | RIPK1HTR1AFPR2TP53HSD11B1 | |
| SCHEMBL25296456 | 0.86 | EIF2AK4 (0.40) | RIPK1KDM4E | |
| SCHEMBL30338824 | 0.86 | EIF2AK4 (0.40) | RIPK1KDM4E | |
| SCHEMBL30338977 | 0.85 | RIPK1 (0.47) | RIPK1HSD11B1PARP1JAK2JAK1 | |
| SCHEMBL25296950 | 0.85 | RIPK1 (0.47) | RIPK1HSD11B1PARP1JAK2JAK1 | |
| SCHEMBL30338624 | 0.85 | RIPK1 (0.40) | RIPK1HTR1AFPR2TP53KDM4E | |
| SCHEMBL25821042 | 0.85 | RIPK1 (0.40) | RIPK1HTR1AFPR2TP53KDM4E | |
| SCHEMBL25817041 | 0.85 | RIPK1 (0.40) | RIPK1HTR1AFPR2TP53KDM4E | |
| SCHEMBL25258724 | 0.85 | RIPK1 (0.58) | RIPK1FPR2HSD11B1JAK2JAK1 | |
| SCHEMBL30338717 | 0.85 | RIPK1 (0.58) | RIPK1FPR2HSD11B1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | claimed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | claimed |
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |