Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 13/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25816984 | 1.00 | RIPK1 (0.43) | RIPK1HTR1AJAK2JAK1JAK3 | |
| SCHEMBL30338771 | 1.00 | RIPK1 (0.43) | RIPK1HTR1AJAK2JAK1JAK3 | |
| SCHEMBL25816985 | 1.00 | RIPK1 (0.43) | RIPK1HTR1AJAK2JAK1JAK3 | |
| SCHEMBL25257714 | 1.00 | RIPK1 (0.43) | RIPK1HTR1AJAK2JAK1JAK3 | |
| SCHEMBL30338823 | 1.00 | RIPK1 (0.43) | RIPK1HTR1AJAK2JAK1JAK3 | |
| SCHEMBL25297184 | 1.00 | RIPK1 (0.43) | RIPK1HTR1AJAK2JAK1JAK3 | |
| SCHEMBL30338558 | 1.00 | RIPK1 (0.43) | RIPK1HTR1AJAK2JAK1JAK3 | |
| SCHEMBL30338708 | 0.87 | RIPK1 (0.50) | RIPK1HTR1ADGAT2 | |
| SCHEMBL25816784 | 0.87 | RIPK1 (0.50) | RIPK1HTR1ADGAT2 | |
| SCHEMBL25816819 | 0.87 | RIPK1 (0.50) | RIPK1HTR1ADGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | claimed |
| CN-116547281-A | Isoxazolidines as RIPK1 inhibitors and uses thereof | 赛诺菲 | 2023-08-04 | — | — | CN | disclosed |
| EP-4157835-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | SANOFI (FR) | 2023-04-05 | — | — | EP | disclosed |