Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 8/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.48 |
| ▸ | CTSA | P10619 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12070458 | 0.87 | CYP2A6 (0.65) | GRM5CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL16547005 | 0.87 | CYP2A6 (0.65) | GRM5CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL10262832 | 0.87 | CYP2A6 (0.65) | GRM5CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL1690651 | 0.87 | CYP2A6 (0.65) | CYP2A6CYP3A4ALDH1A1CYP1A2NPY5R | |
| SCHEMBL2751114 | 0.87 | CYP2A6 (0.65) | CYP2A6CYP3A4ALDH1A1CYP1A2NPY5R | |
| SCHEMBL12131368 | 0.83 | CYP2A6 (0.60) | GRM5CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL22693745 | 0.83 | CYP2A6 (0.60) | GRM5CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL27430951 | 0.83 | CYP2A6 (0.60) | GRM5CYP2A6CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL5527335 | 0.83 | CYP2A6 (0.60) | CYP2A6CYP3A4ALDH1A1CYP1A2NPY5R | |
| SCHEMBL10263457 | 0.81 | CYP19A1 (0.59) | GRM5CYP2A6CYP3A4ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230086703-A1 | N-(4-(5-chloropyridin-3-yl)phenyl)-2-(2-(cyclopropanesulfonamido)pyrimidin-4-yl) butanamide derivatives and related compounds as human CTPS1 inhibitors for the treatment of proliferative diseases | STEP PHARMA S.A.S. (FR) | 2023-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230086703-A1 | N-(4-(5-chloropyridin-3-yl)phenyl)-2-(2-(cyclopropanesulfonamido)pyrimidin-4-yl) butanamide derivatives and related compounds as human CTPS1 inhibitors for the treatment of proliferative diseases | CTPS1, CTPS2, CERS2 | GRM5 4783/4885CYP2A6 1643/4885CYP3A4 2600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.