Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (+/-)Nicotine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 4/20 | 0.94 |
| ▸ | CHRNA4 known ✓ | P43681 | 4/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.94 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.94 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.94 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.94 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.94 |
| ▸ | LMNA | P02545 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.94 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.94 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.94 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.94 |
| ▸ | HTR3B | O95264 | 1/20 | 0.94 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.94 |
| ▸ | CHRNG | P07510 | 1/20 | 0.94 |
| ▸ | MAPT | P10636 | 1/20 | 0.94 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.94 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.94 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.94 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+/-)Nicotine SCHEMBL676683 | 1.00 | ALDH1A1 (0.94) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL4615064 | 0.98 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL29352733 | 0.98 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL27784105 | 0.98 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL15561440 | 0.98 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL2390652 | 0.98 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL15561442 | 0.98 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL4615066 | 0.98 | ALDH1A1 (0.97) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| Nicotine SCHEMBL9383177 | 0.97 | ALDH1A1 (0.94) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 | |
| (+/-)Nicotine SCHEMBL9383182 | 0.97 | ALDH1A1 (0.94) | ALDH1A1CHRNA7CHRNB2CHRNA4CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4635318-A2 | DEVICE, SYSTEM AND METHOD | Imperial Tobacco Limited (GB) | 2025-10-22 | — | — | EP | disclosed |
| US-20250288757-A1 | AEROSOLIZATION USING TWO AEROSOL GENERATORS | IMPERIAL TOBACCO LTD (GB) | 2025-09-18 | — | — | US | disclosed |
| EP-3758526-B1 | SUBSTITUTE SMOKING DEVICE COMPRISING PASSIVE AEROSOL GENERATION | IMPERIAL TOBACCO LTD (GB) | 2025-09-10 | — | — | EP | disclosed |
| US-12337105-B2 | Aerosolization using two aerosol generators | IMPERIAL TOBACCO LIMITED (GB) | 2025-06-24 | — | — | US | disclosed |
| US-20240325662-A1 | AEROSOLIZATION USING TWO AEROSOL GENERATORS | IMPERIAL TOBACCO LIMITED (GB) | 2024-10-03 | — | — | US | disclosed |
| EP-3684206-B1 | DEVICE AND UNIT | IMPERIAL TOBACCO LTD (GB) | 2024-08-21 | — | — | EP | disclosed |
| EP-4400134-A2 | DEVICE AND UNIT | Imperial Tobacco Limited (GB) | 2024-07-17 | — | — | EP | disclosed |
| US-12029846-B2 | Aerosolization using two aerosol generators | IMPERIAL TOBACCO LIMITED (GB) | 2024-07-09 | — | — | US | disclosed |
| US-20230293833-A1 | AEROSOLIZATION USING TWO AEROSOL GENERATORS | IMPERIAL TOBACCO LIMITED (GB) | 2023-09-21 | — | — | US | disclosed |
| EP-3758525-B1 | SUBSTITUTE SMOKING DEVICE COMPRISING MULTIPLE AEROSOLS AND PASSIVE AEROSOL GENERATION | IMPERIAL TOBACCO LTD (GB) | 2023-08-02 | — | — | EP | disclosed |
| US-11633556-B2 | Aerosolization using two aerosol generators | IMPERIAL TOBACCO LIMITED (GB) | 2023-04-25 | — | — | US | disclosed |