Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 1/20 | 0.56 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 5/20 | 0.44 |
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20001680 | 1.00 | RHEB (0.56) | RHEBPKN1PKN2APPCHEK2 | |
| SCHEMBL1842216 | 0.85 | PKN1 (0.59) | RHEBPKN1PKN2CHEK2DGAT1 | |
| SCHEMBL418300 | 0.84 | HPSE (0.50) | HPSEKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL14683901 | 0.84 | HPSE (0.50) | HPSEKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL3333407 | 0.82 | RHEB (0.68) | RHEBPKN1PKN2APPCHEK2 | |
| SCHEMBL8412123 | 0.82 | RHEB (0.59) | RHEBPKN1PKN2CHEK2DGAT1 | |
| SCHEMBL19994470 | 0.82 | RHEB (0.59) | RHEBPKN1PKN2APPCHEK2 | |
| SCHEMBL1842081 | 0.82 | RHEB (0.59) | RHEBPKN1PKN2CHEK2DGAT1 | |
| SCHEMBL28267390 | 0.81 | CHEK2 (0.61) | RHEBPKN1PKN2CHEK2DGAT1 | |
| SCHEMBL21705379 | 0.81 | HDAC6 (0.59) | RHEBPKN1PKN2CHEK2DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515904-B1 | BENZOIMIDAZOLE DERIVATIVES AS ANTICANCER AGENTS | CENTRE LEON BERARD (FR) | 2024-01-17 | — | — | EP | disclosed |
| CN-110234640-B | Benzimidazole derivatives as anticancer agents | 利昂贝拉尔中心 | 2023-04-07 | — | — | CN | disclosed |