Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 6/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2238191 | 0.97 | BDKRB1 (0.37) | BDKRB1EP300HIF1AMCHR1KCNH2 | |
| SCHEMBL2239341 | 0.96 | BDKRB1 (0.37) | BDKRB1EP300HIF1AMCHR1AVPR1B | |
| SCHEMBL2239214 | 0.92 | PDK1 (0.38) | BDKRB1EP300HIF1AMCHR1AVPR1B | |
| SCHEMBL2240327 | 0.92 | BDKRB1 (0.37) | BDKRB1EP300HIF1AMCHR1AVPR1B | |
| SCHEMBL2239655 | 0.92 | EP300 (0.36) | BDKRB1EP300HIF1AMCHR1AVPR1B | |
| SCHEMBL2236733 | 0.92 | MCHR1 (0.36) | BDKRB1EP300HIF1AMCHR1KCNH2 | |
| SCHEMBL2239323 | 0.91 | EP300 (0.38) | BDKRB1EP300HIF1AMCHR1AVPR1B | |
| SCHEMBL2238132 | 0.90 | EP300 (0.36) | BDKRB1EP300HIF1AMCHR1 | |
| SCHEMBL2239439 | 0.90 | EP300 (0.38) | BDKRB1EP300HIF1AMCHR1AVPR1B | |
| SCHEMBL2240747 | 0.89 | BDKRB1 (0.42) | BDKRB1MCHR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500783-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2331518-A1 | NEW BRADYKININ B1 ANTAGONISTS | Evotec AG (DE) | 2011-06-15 | — | — | EP | claimed |
| WO-2010020556-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-02-25 | — | — | WO | claimed |