Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | TYR | P14679 | 1/20 | 0.51 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.51 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1957586 | 1.00 | EGFR (0.59) | EGFRGSK3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL31105770 | 0.89 | KDM4E (0.68) | EGFRGSK3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3210785 | 0.89 | KDM4E (0.68) | EGFRGSK3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4403031 | 0.84 | EGFR (0.55) | EGFRGSK3BCYP1A2ALDH1A1KDM4E | |
| SCHEMBL11996253 | 0.83 | KDM4E (0.59) | EGFRGSK3BCYP1A2ALDH1A1KDM4E | |
| SCHEMBL6303683 | 0.83 | ALDH1A1 (0.58) | EGFRGSK3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4715292 | 0.81 | EGFR (0.46) | EGFRGSK3BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28970665 | 0.81 | ALDH1A1 (0.53) | EGFRGSK3BCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL27003032 | 0.81 | ALDH1A1 (0.53) | EGFRGSK3BCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL16764730 | 0.81 | TRIM24 (0.60) | EGFRCYP1A2ALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4416146-A1 | SUBSTITUTED 1H-PYRAZOLO [4,3-C] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF | Lomond Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | disclosed |
| WO-2023064133-A1 | SUBSTITUTED 1H-PYRAZOLO [4,3-c] QUINOLINES, METHODS OF PREPARATION, AND USE THEREOF | LOMOND THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | disclosed |