Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 13/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.46 |
| ▸ | CDC42BPB | Q9Y5S2 | 5/20 | 0.46 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25198211 | 1.00 | LRRK2 (0.55) | LRRK2ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL26174621 | 0.85 | ROCK2 (0.55) | LRRK2ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL30347318 | 0.84 | LRRK2 (0.51) | LRRK2ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL25518161 | 0.84 | LRRK2 (0.51) | LRRK2ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL30348428 | 0.82 | LRRK2 (0.48) | LRRK2ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL25156870 | 0.82 | LRRK2 (0.48) | LRRK2ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL26175335 | 0.78 | ALK (0.58) | — | |
| SCHEMBL26176230 | 0.76 | MAPT (0.47) | LRRK2ROCK2ROCK1CDC42BPBMAPK1 | |
| SCHEMBL25203990 | 0.75 | LRRK2 (0.53) | LRRK2ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL25196460 | 0.75 | LRRK2 (0.53) | LRRK2ROCK2ROCK1CDC42BPBCDC42BPA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |