Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 16/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25224210 | 1.00 | TDO2 (0.45) | TDO2BRD4CLK2CLK3DYRK1A | |
| SCHEMBL25202411 | 0.91 | BRD4 (0.47) | TDO2BRD4CLK2CLK3DYRK1A | |
| SCHEMBL25157003 | 0.90 | TDO2 (0.44) | TDO2BRD4CLK2CLK3DYRK1A | |
| SCHEMBL25204907 | 0.90 | TDO2 (0.43) | TDO2BRD4CLK2CLK3DYRK1A | |
| SCHEMBL30349296 | 0.90 | TDO2 (0.44) | TDO2BRD4CLK2CLK3DYRK1A | |
| SCHEMBL25215082 | 0.90 | TDO2 (0.44) | TDO2BRD4CLK2CLK3DYRK1A | |
| SCHEMBL30347337 | 0.89 | TDO2 (0.50) | TDO2BRD4CLK2CLK3DYRK1A | |
| SCHEMBL25157340 | 0.89 | TDO2 (0.50) | TDO2BRD4CLK2CLK3DYRK1A | |
| SCHEMBL25197024 | 0.88 | TDO2 (0.47) | TDO2BRD4CLK2CLK3DYRK1A | |
| SCHEMBL25158596 | 0.88 | TDO2 (0.47) | TDO2BRD4CLK2CLK3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |