Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.40 |
| ▸ | CLK3 | P49761 | 3/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | LATS1 | O95835 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.33 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25519967 | 1.00 | TDO2 (0.50) | TDO2DYRK1ACLK3CLK2BRD4 | |
| SCHEMBL25157609 | 0.94 | TDO2 (0.50) | TDO2DYRK1ACLK3CLK2BRD4 | |
| SCHEMBL30407329 | 0.94 | TDO2 (0.50) | TDO2DYRK1ACLK3CLK2BRD4 | |
| SCHEMBL25519972 | 0.92 | TDO2 (0.52) | TDO2DYRK1ACLK3CLK2BRD4 | |
| SCHEMBL25519960 | 0.92 | TDO2 (0.52) | TDO2DYRK1ACLK3CLK2BRD4 | |
| SCHEMBL25519991 | 0.87 | TDO2 (0.47) | TDO2DYRK1ACLK3CLK2BRD4 | |
| SCHEMBL30407103 | 0.87 | TDO2 (0.47) | TDO2DYRK1ACLK3CLK2BRD4 | |
| SCHEMBL30347844 | 0.86 | TDO2 (0.55) | TDO2DYRK1ACLK3CLK2BRD4 | |
| SCHEMBL25156876 | 0.86 | TDO2 (0.55) | TDO2DYRK1ACLK3CLK2BRD4 | |
| SCHEMBL25519982 | 0.86 | TDO2 (0.50) | TDO2DYRK1ACLK3CLK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |