Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 13/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 13/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.38 |
| ▸ | CDK2 | P24941 | 9/20 | 0.38 |
| ▸ | CDK9 | P50750 | 9/20 | 0.38 |
| ▸ | CDK7 | P50613 | 6/20 | 0.38 |
| ▸ | CCNH | P51946 | 6/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 6/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25207829 | 1.00 | CCNK (0.38) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL25266090 | 0.90 | RET (0.45) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL25203199 | 0.90 | RET (0.45) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL25215129 | 0.88 | ROCK2 (0.37) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL30346424 | 0.88 | ROCK2 (0.37) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL25215131 | 0.88 | ROCK2 (0.37) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL25158434 | 0.86 | CDC7 (0.42) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL25157917 | 0.84 | BRD4 (0.39) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL30348704 | 0.84 | BRD4 (0.39) | CCNKCDK12CCNT1CCNE1CDK2 | |
| SCHEMBL25158420 | 0.84 | DYRK1A (0.44) | CCNT1CDK2CDK9CDK7CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| US-20230167133-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2023-06-01 | — | — | US | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167133-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF | DYRK1A, DYRK1B, DYRK2 | CCNK 44/4885CDK12 606/4885CCNT1 1162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.