Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 5/20 | 0.48 |
| ▸ | CDK2 | P24941 | 7/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.46 |
| ▸ | CDK7 | P50613 | 3/20 | 0.46 |
| ▸ | CCNH | P51946 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.44 |
| ▸ | CDK9 | P50750 | 4/20 | 0.44 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | WEE1 | P30291 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30347270 | 0.91 | TTK (0.49) | TTKCDK2CDK1CCNB1CDK7 | |
| SCHEMBL30346733 | 0.87 | TTK (0.44) | TTKCDK2CDK1CCNB1CDK7 | |
| SCHEMBL30346516 | 0.85 | TTK (0.47) | TTKCDK2JAK2PTK2JAK3 | |
| SCHEMBL25208686 | 0.84 | CDK2 (0.58) | CDK2CDK1CCNB1CDK7CCNH | |
| SCHEMBL30406799 | 0.84 | CDK2 (0.58) | CDK2CDK1CCNB1CDK7CCNH | |
| SCHEMBL4256785 | 0.79 | JAK2 (0.57) | TTKCDK2CDK1CCNB1CDK7 | |
| SCHEMBL30347590 | 0.78 | TTK (0.45) | TTKCDK2CDK1CCNB1CDK7 | |
| SCHEMBL30348674 | 0.78 | TGFBR1 (0.41) | TTK | |
| SCHEMBL30347298 | 0.78 | JAK2 (0.41) | TTKCDK2CDK1CCNB1CCNE1 | |
| SCHEMBL30348029 | 0.77 | TTK (0.37) | TTKCDK2JAK2PTK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |