Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK7 | P50613 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25158420 | 1.00 | DYRK1A (0.44) | DYRK1ARETMAPK1BRD4ABL1 | |
| SCHEMBL25158434 | 0.91 | CDC7 (0.42) | DYRK1ARETMAPK1BRD4ABL1 | |
| SCHEMBL30348692 | 0.88 | DYRK1A (0.47) | DYRK1ARETBRD4ABL1CLK2 | |
| SCHEMBL25158417 | 0.88 | DYRK1A (0.47) | DYRK1ARETBRD4ABL1CLK2 | |
| SCHEMBL25157917 | 0.87 | BRD4 (0.39) | DYRK1AMAPK1BRD4ABL1CLK2 | |
| SCHEMBL30348704 | 0.87 | BRD4 (0.39) | DYRK1AMAPK1BRD4ABL1CLK2 | |
| SCHEMBL25203199 | 0.87 | RET (0.45) | DYRK1ARETBRD4ABL1CLK2 | |
| SCHEMBL25266090 | 0.87 | RET (0.45) | DYRK1ARETBRD4ABL1CLK2 | |
| SCHEMBL25215131 | 0.86 | ROCK2 (0.37) | DYRK1ARETBRD4ABL1CLK2 | |
| SCHEMBL25215129 | 0.86 | ROCK2 (0.37) | DYRK1ARETBRD4ABL1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |