Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.56 |
| ▸ | FLT3 | P36888 | 4/20 | 0.56 |
| ▸ | CDK1 | P06493 | 4/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.56 |
| ▸ | CDK7 | P50613 | 4/20 | 0.56 |
| ▸ | CCNH | P51946 | 4/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.56 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.56 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CLK3 | P49761 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.48 |
| ▸ | CDK9 | P50750 | 4/20 | 0.48 |
| ▸ | WEE1 | P30291 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25218717 | 1.00 | CDK2 (0.56) | CDK2FLT3CDK1CCNB1CDK7 | |
| SCHEMBL25157096 | 0.87 | CLK2 (0.62) | CDK2FLT3CDK1CCNB1CDK7 | |
| SCHEMBL30347771 | 0.87 | CLK2 (0.62) | CDK2FLT3CDK1CCNB1CDK7 | |
| SCHEMBL30348555 | 0.86 | CLK2 (0.49) | CDK2FLT3CDK1CCNB1CDK7 | |
| SCHEMBL25157128 | 0.86 | CLK2 (0.49) | CDK2FLT3CDK1CCNB1CDK7 | |
| SCHEMBL25523390 | 0.83 | DYRK1A (0.60) | CDK2FLT3CDK1CCNB1CDK7 | |
| SCHEMBL30399490 | 0.82 | CDK2 (0.51) | CDK2FLT3CDK1CCNB1CDK7 | |
| SCHEMBL26176190 | 0.82 | CDK2 (0.51) | CDK2FLT3CDK1CCNB1CDK7 | |
| SCHEMBL25198845 | 0.80 | DYRK1A (0.39) | CDK2FLT3CDK1CCNB1CLK2 | |
| SCHEMBL30406338 | 0.80 | DYRK1A (0.39) | CDK2FLT3CDK1CCNB1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250129104-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF | TENARX, INC. | 2025-04-24 | — | — | US | claimed |
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| US-20230167133-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF | VICKERS VENTURE FUND VI PTE. LTD. (SG) | 2023-06-01 | — | — | US | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230167133-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF | DYRK1A, DYRK1B, DYRK2 | CDK2 72/4885FLT3 1727/4885CDK1 192/4885 |
| US-20250129104-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AND USES THEREOF | DYRK1A, DYRK1B, DYRK2 | CDK2 72/4885FLT3 1727/4885CDK1 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.