Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.46 |
| ▸ | TDO2 | P48775 | 12/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | IL2 | P60568 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25197263 | 1.00 | DYRK1A (0.46) | DYRK1ADYRK1BTDO2CLK2CLK3 | |
| SCHEMBL25220651 | 0.90 | DYRK1A (0.48) | DYRK1ADYRK1BTDO2CLK2CLK3 | |
| SCHEMBL30348435 | 0.90 | DYRK1A (0.48) | DYRK1ADYRK1BTDO2CLK2CLK3 | |
| SCHEMBL25204091 | 0.90 | TDO2 (0.48) | DYRK1ATDO2CLK2RETCDK2 | |
| SCHEMBL30347404 | 0.90 | TDO2 (0.48) | DYRK1ATDO2CLK2RETCDK2 | |
| SCHEMBL25215195 | 0.88 | TDO2 (0.45) | DYRK1ATDO2CLK2CLK3RET | |
| SCHEMBL25158118 | 0.88 | TDO2 (0.43) | DYRK1ADYRK1BTDO2CLK2CLK3 | |
| SCHEMBL25195580 | 0.88 | TDO2 (0.45) | DYRK1ATDO2CLK2CLK3RET | |
| SCHEMBL25215193 | 0.88 | TDO2 (0.45) | DYRK1ATDO2CLK2CLK3RET | |
| SCHEMBL25265919 | 0.88 | TDO2 (0.45) | DYRK1ATDO2CLK2CLK3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |