Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.50 |
| ▸ | CLK1 | P49759 | 13/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25157913 | 1.00 | TGFBR1 (0.50) | TGFBR1CLK1LRRK2 | |
| SCHEMBL26176746 | 0.88 | TGFBR1 (0.51) | TGFBR1CLK1 | |
| SCHEMBL30400090 | 0.88 | TGFBR1 (0.51) | TGFBR1CLK1 | |
| SCHEMBL30399543 | 0.83 | CLK1 (0.52) | TGFBR1CLK1 | |
| SCHEMBL26175334 | 0.83 | CLK1 (0.52) | TGFBR1CLK1 | |
| SCHEMBL30399301 | 0.82 | TGFBR1 (0.52) | TGFBR1CLK1 | |
| SCHEMBL26176229 | 0.82 | TGFBR1 (0.52) | TGFBR1CLK1 | |
| SCHEMBL30347299 | 0.81 | LRRK2 (0.47) | TGFBR1CLK1LRRK2 | |
| SCHEMBL25518317 | 0.81 | LRRK2 (0.47) | TGFBR1CLK1LRRK2 | |
| SCHEMBL25158049 | 0.80 | LRRK2 (0.47) | CLK1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |