Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.56 |
| ▸ | CLK2 | P49760 | 1/20 | 0.56 |
| ▸ | CLK3 | P49761 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 10/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29813554 | 0.81 | EGFR (0.62) | EGFR | |
| SCHEMBL17112501 | 0.78 | EGFR (0.48) | EGFR | |
| SCHEMBL26640450 | 0.76 | CLK2 (0.49) | DYRK1ACLK2CLK3EGFRMTOR | |
| SCHEMBL30346524 | 0.74 | DYRK1A (0.82) | DYRK1ACLK2CLK3EGFRMTOR | |
| SCHEMBL25210650 | 0.74 | DYRK1A (0.82) | DYRK1ACLK2CLK3EGFRMTOR | |
| SCHEMBL25562899 | 0.74 | DYRK1A (0.76) | DYRK1ACLK2CLK3MTORSMG1 | |
| SCHEMBL25157358 | 0.74 | DYRK1A (0.73) | DYRK1ACLK2CLK3EGFRMTOR | |
| SCHEMBL30347590 | 0.73 | TTK (0.45) | DYRK1ACLK2CLK3EGFRMTOR | |
| SCHEMBL29652309 | 0.73 | DYRK1A (0.64) | DYRK1ACLK2IRAK4 | |
| SCHEMBL25157096 | 0.73 | CLK2 (0.62) | DYRK1ACLK2CLK3EGFRMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415818-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2024-08-21 | — | — | EP | claimed |
| WO-2023064361-A1 | 7H-PYRROLO[2,3-D]PYRIMIDINES AND PREPARATION AS DYRK1A INHIBITORS | BIOSPLICE THERAPEUTICS, INC. (US) | 2023-04-20 | — | — | WO | claimed |