Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.62 |
| ▸ | TTK | P33981 | 1/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.58 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 6/20 | 0.55 |
| ▸ | CCND1 | P24385 | 4/20 | 0.55 |
| ▸ | CCND2 | P30279 | 4/20 | 0.55 |
| ▸ | CCND3 | P30281 | 4/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.55 |
| ▸ | CDK1 | P06493 | 2/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.55 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.55 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29277198 | 0.86 | SYK (0.60) | TTKCDK4CCND1CCND2CCND3 | |
| SCHEMBL3814909 | 0.85 | EGFR (0.57) | EGFRALKCDK4CCND1CCND2 | |
| SCHEMBL1072153 | 0.84 | SYK (0.55) | EGFRCDK4CCND1CDK1FGFR1 | |
| SCHEMBL3583145 | 0.84 | AURKA (0.64) | EGFRALKMAP4K1CDK4CCND1 | |
| SCHEMBL10346428 | 0.82 | CDK4 (0.61) | EGFRALKMAP4K1CDK4CCND1 | |
| SCHEMBL30349229 | 0.81 | DYRK1A (0.56) | EGFR | |
| SCHEMBL23010815 | 0.79 | TTK (0.68) | EGFRTTK | |
| SCHEMBL17112501 | 0.79 | EGFR (0.48) | EGFR | |
| SCHEMBL27174693 | 0.79 | MAP4K1 (0.73) | EGFRALKMAP4K1CDK4CCND1 | |
| SCHEMBL3971076 | 0.78 | TTK (0.66) | EGFRTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220242870-A1 | HETEROCYCLE-FUSED PYRIMIDINE DERIVATIVE AND USE THEREOF | VORONOIBIO INC. (KR) | 2022-08-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220242870-A1 | HETEROCYCLE-FUSED PYRIMIDINE DERIVATIVE AND USE THEREOF | CDK4, CDK6, CDK16 | EGFR 1516/4885TTK 34/4885ALK 1214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.