Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.52 |
| ▸ | GSPT1 | P15170 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26090828 | 1.00 | CRBN (0.52) | CRBNDDB1GSPT1MAPTMEN1 | |
| SCHEMBL26087906 | 0.93 | CRBN (0.45) | CRBNDDB1GSPT1MAPTMEN1 | |
| SCHEMBL26087759 | 0.87 | CRBN (0.39) | CRBNDDB1GSPT1ALDH1A1LMNA | |
| SCHEMBL30349520 | 0.87 | CRBN (0.39) | CRBNDDB1GSPT1ALDH1A1LMNA | |
| SCHEMBL26089566 | 0.86 | LMNA (0.40) | CRBNDDB1GSPT1MAPTMEN1 | |
| SCHEMBL26086762 | 0.86 | CRBN (0.55) | CRBNDDB1GSPT1MEN1KMT2A | |
| SCHEMBL26434916 | 0.86 | CRBN (0.55) | CRBNDDB1GSPT1MEN1KMT2A | |
| SCHEMBL26133407 | 0.85 | CRBN (0.52) | CRBNDDB1GSPT1MAPTKMT2A | |
| SCHEMBL30349500 | 0.83 | CRBN (0.51) | CRBNDDB1GSPT1KDM4EL3MBTL1 | |
| SCHEMBL26089304 | 0.83 | CRBN (0.51) | CRBNDDB1GSPT1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023069731-A1 | COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |