Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.57 |
| ▸ | CACNA1C | Q13936 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.57 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.57 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.57 |
| ▸ | SCN1A | P35498 | 3/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027420 | 0.94 | CYP2C9 (0.63) | ADORA3CYP2C9CYP1A2KDM4ECYP3A4 | |
| SCHEMBL29676356 | 0.94 | CYP2C9 (0.63) | ADORA3CYP2C9CYP1A2KDM4ECYP3A4 | |
| SCHEMBL3034979 | 0.90 | CACNA1B (0.43) | ADORA3CYP2C9CYP1A2KDM4ECYP3A4 | |
| SCHEMBL3024688 | 0.89 | KDM4E (0.57) | ADORA3CYP2C9CYP1A2KDM4ECYP3A4 | |
| SCHEMBL3034394 | 0.87 | ADORA3 (0.68) | ADORA3CYP2C9CYP1A2KDM4ECYP3A4 | |
| SCHEMBL8215642 | 0.86 | CYP2C9 (0.54) | ADORA3CYP2C9CYP1A2KDM4ECYP3A4 | |
| SCHEMBL14273535 | 0.84 | KDM4E (0.52) | ADORA3CYP2C9CYP1A2KDM4ECYP3A4 | |
| SCHEMBL7414856 | 0.84 | NR1I2 (0.67) | ADORA3CYP2C9CYP1A2KDM4ECYP3A4 | |
| SCHEMBL3026759 | 0.84 | KDM4E (0.62) | ADORA3CYP2C9CYP1A2KDM4ECYP3A4 | |
| SCHEMBL28736000 | 0.83 | ADORA3 (0.51) | ADORA3CYP2C9CYP1A2KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20100215735-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-16 | — | — | US | disclosed |
| US-20070185130-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-09 | — | — | US | disclosed |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ALZHEIMER'S INSTITUTE OF AMERICA, INC. | 2007-02-15 | — | — | US | disclosed |
| US-20060188938-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ARCHER PHARMACEUTICALS, INC. | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | ADORA3 560/4885CYP2C9 4440/4885CYP1A2 3330/4885 |
| US-20070185130-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | ADORA3 560/4885CYP2C9 4440/4885CYP1A2 3330/4885 |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | ADORA3 560/4885CYP2C9 4440/4885CYP1A2 3330/4885 |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | APP, PSEN1, PSEN2 | ADORA3 560/4885CYP2C9 4440/4885CYP1A2 3330/4885 |
| US-20060188938-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | ADORA3 560/4885CYP2C9 4440/4885CYP1A2 3330/4885 |
| US-20100215735-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | APP, PSEN1, PSEN2 | ADORA3 560/4885CYP2C9 4440/4885CYP1A2 3330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.