Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 2/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21752728 | 1.00 | HCRTR1 (0.42) | HCRTR1HCRTR2GRIN1GRIN2BKMT2A | |
| SCHEMBL30352861 | 0.92 | KMT2A (0.41) | HCRTR1HCRTR2KMT2AALOX15SMN1; SMN2 | |
| SCHEMBL21752709 | 0.92 | KMT2A (0.41) | HCRTR1HCRTR2KMT2AALOX15SMN1; SMN2 | |
| SCHEMBL23780128 | 0.87 | TRPV1 (0.36) | KMT2AALOX15NR2F2NPC1TRPV1 | |
| SCHEMBL31109330 | 0.87 | TRPV1 (0.36) | KMT2AALOX15NR2F2NPC1TRPV1 | |
| SCHEMBL21765013 | 0.87 | HCRTR1 (0.41) | HCRTR1HCRTR2GRIN1GRIN2BKMT2A | |
| SCHEMBL21752594 | 0.86 | KMT2A (0.42) | KMT2AALOX15NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21752477 | 0.85 | KMT2A (0.43) | KMT2AALOX15NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL21752617 | 0.85 | KMT2A (0.44) | KMT2AALOX15NPC1RAB9AIKBKB | |
| SCHEMBL30352925 | 0.85 | KMT2A (0.44) | KMT2AALOX15NPC1RAB9AIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12576087-B2 | Aryloxypiperidine pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors | MERCK SHARP & DOHME LLC (US) | 2026-03-17 | — | — | US | disclosed |
| EP-3840747-B1 | NOVEL ARYLOXYPIPERIDINE PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-03-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12576087-B2 | Aryloxypiperidine pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors | IDO1, IDO2, TPH1 | HCRTR1 68/4885HCRTR2 73/4885GRIN1 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.