Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.87 |
| ▸ | FLT3 | P36888 | 3/20 | 0.87 |
| ▸ | BLK | P51451 | 2/20 | 0.87 |
| ▸ | BTK | Q06187 | 4/20 | 0.75 |
| ▸ | JAK3 | P52333 | 3/20 | 0.71 |
| ▸ | GAK | O14976 | 1/20 | 0.66 |
| ▸ | FES | P07332 | 1/20 | 0.66 |
| ▸ | FER | P16591 | 1/20 | 0.66 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.66 |
| ▸ | TEC | P42680 | 1/20 | 0.66 |
| ▸ | CLK1 | P49759 | 1/20 | 0.66 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.66 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18294436 | 1.00 | EGFR (0.87) | EGFRFLT3BLKBTKJAK3 | |
| SCHEMBL30192805 | 0.93 | EGFR (1.00) | EGFRFLT3BLKBTKJAK3 | |
| SCHEMBL16680603 | 0.93 | EGFR (1.00) | EGFRFLT3BLKBTKJAK3 | |
| SCHEMBL20080224 | 0.90 | EGFR (0.70) | EGFRFLT3BLKBTKJAK3 | |
| SCHEMBL29572941 | 0.90 | EGFR (0.86) | EGFRFLT3BLKBTKJAK3 | |
| SCHEMBL18294441 | 0.90 | EGFR (0.86) | EGFRFLT3BLKBTKJAK3 | |
| SCHEMBL15992590 | 0.89 | EGFR (0.87) | EGFRBTKJAK3 | |
| SCHEMBL18294437 | 0.89 | EGFR (0.82) | EGFRFLT3BLKBTKJAK3 | |
| SCHEMBL18294430 | 0.86 | EGFR (0.87) | EGFRFLT3BLKBTKJAK3 | |
| SCHEMBL30353469 | 0.86 | EGFR (0.87) | EGFRFLT3BLKBTKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107922417-B | Use of pteridinone derivatives as EGFR inhibitors | 上海壹典医药科技开发有限公司 | 2023-01-24 | — | — | CN | disclosed |