Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.41 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 6/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | MC5R | P33032 | 1/20 | 0.31 |
| ▸ | MC3R | P41968 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20153296 | 0.77 | UHRF1 (0.51) | NNMTUHRF1PDE3BPDE3ANUDT1 | |
| SCHEMBL16195787 | 0.74 | UHRF1 (0.45) | NNMTUHRF1PDE3BPDE3A | |
| SCHEMBL24094565 | 0.73 | MC4R (0.47) | MC4RPDE3BPDE3AMC5RMC3R | |
| SCHEMBL30323413 | 0.73 | MC4R (0.47) | MC4RPDE3BPDE3AMC5RMC3R | |
| Hydrochloric Acid SCHEMBL31099030 | 0.72 | MC4R (0.47) | MC4RPDE3BPDE3AMC5RMC3R | |
| Hydrochloric Acid SCHEMBL30184821 | 0.72 | MC4R (0.47) | MC4RPDE3BPDE3AMC5RMC3R | |
| SCHEMBL21281647 | 0.72 | UHRF1 (0.42) | NNMTUHRF1PDE3BPDE3A | |
| SCHEMBL12895015 | 0.72 | UHRF1 (0.42) | NNMTUHRF1PDE3BPDE3A | |
| SCHEMBL30355174 | 0.72 | MC4R (0.46) | MC4RPDE3BPDE3AMC5RMC3R | |
| SCHEMBL23912895 | 0.71 | UHRF1 (0.41) | NNMTUHRF1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4161927-A1 | SPIRO COMPOUNDS AS MELANOCORTIN 4 RECEPTOR ANTAGONISTS AND USES THEREOF | Pfizer Inc. (US) | 2023-04-12 | — | — | EP | claimed |