Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 6/20 | 0.65 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29787279 | 1.00 | ADRA2C (0.65) | ADRA2CITGB3ITGA2BMAPK8HRH3 | |
| SCHEMBL24183492 | 1.00 | ADRA2C (0.65) | ADRA2CITGB3ITGA2BMAPK8HRH3 | |
| SCHEMBL25124336 | 0.98 | ADRA2C (0.66) | ADRA2CITGB3ITGA2BMAPK8HRH3 | |
| SCHEMBL29787271 | 0.91 | ADRA2C (0.68) | ADRA2CITGB3ITGA2BMAPK8HRH3 | |
| SCHEMBL24183657 | 0.91 | ADRA2C (0.68) | ADRA2CITGB3ITGA2BMAPK8HRH3 | |
| SCHEMBL24183576 | 0.90 | ADRA2C (0.79) | ADRA2CITGB3ITGA2BMAPK8HRH3 | |
| SCHEMBL29787265 | 0.89 | ADRA2C (0.76) | ADRA2CITGB3ITGA2BMAPK8HRH3 | |
| SCHEMBL25124266 | 0.89 | ADRA2C (0.76) | ADRA2CITGB3ITGA2BMAPK8HRH3 | |
| SCHEMBL24183679 | 0.89 | ADRA2C (0.84) | ADRA2CMAPK8TMPRSS15 | |
| SCHEMBL24183684 | 0.88 | ADRA2C (0.70) | ADRA2CITGB3ITGA2BMAPK8HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118434414-A | Combinations of alpha 2-adrenoceptor subtype C (alpha-2C) antagonists and muscarinic receptor antagonists for the treatment of sleep apnea | 拜耳公司 | 2024-08-02 | — | — | CN | disclosed |
| EP-4175954-A1 | COMBINATION OF AN ALPHA2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONIST WITH A TASK1/3 CHANNEL BLOCKER FOR THE TREATMENT OF SLEEP APNEA | Bayer Aktiengesellschaft (DE) | 2023-05-10 | — | — | EP | disclosed |
| CN-116057057-A | Conjugates of alpha 2-adrenoceptor subtype C (alpha-2C) antagonists and TASK1/3 channel blockers for the treatment of sleep apnea | 拜耳公司 | 2023-05-02 | — | — | CN | disclosed |