Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 12/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22041916 | 1.00 | RET (0.47) | RETCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL30877283 | 0.83 | RET (0.49) | RETCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL20070844 | 0.81 | RET (0.53) | RET | |
| SCHEMBL29483174 | 0.81 | RET (0.53) | RET | |
| SCHEMBL29483113 | 0.79 | RET (0.44) | RET | |
| SCHEMBL22041878 | 0.79 | RET (0.44) | RET | |
| SCHEMBL20153225 | 0.78 | CHRNB2 (0.52) | RETCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL22666884 | 0.75 | ACACB (0.44) | ACACBPDE10A | |
| SCHEMBL23555019 | 0.75 | CHRNB2 (0.49) | RETCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL22811911 | 0.75 | CHRNB2 (0.49) | RETCHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111285886-B | Substituted pyrazolo [1,5-a ] pyridine compounds, compositions comprising the same and uses thereof | 深圳市塔吉瑞生物医药有限公司 | 2023-04-11 | — | — | CN | disclosed |