Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20411048 | 1.00 | GRM5 (0.43) | GRM5CYP1A2CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL30360492 | 0.87 | GRM5 (0.44) | GRM5CYP1A2CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL20411157 | 0.87 | GRM5 (0.44) | GRM5CYP1A2CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL30360515 | 0.83 | NPC1 (0.47) | GRM5CYP1A2CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL20411049 | 0.83 | NPC1 (0.47) | GRM5CYP1A2CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL17609062 | 0.76 | NPC1 (0.43) | GRM5CYP1A2CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL23276709 | 0.75 | GRM5 (0.60) | GRM5CYP1A2CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL30360502 | 0.73 | NPC1 (0.48) | GRM5CYP1A2CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL20410742 | 0.73 | NPC1 (0.48) | GRM5CYP1A2CYP3A4SMN1; SMN2NPC1 | |
| SCHEMBL27809863 | 0.72 | KMT2A (0.49) | SMN1; SMN2NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3571198-B1 | BICYCLIC AMINES AS JAK KINASE INHIBITORS | LEO PHARMA AS (DK) | 2023-02-01 | — | — | EP | disclosed |