Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.36 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26516732 | 1.00 | MAP4K1 (0.41) | MAP4K1ACVR1FYNPIK3CAPIK3CD | |
| SCHEMBL26516557 | 0.88 | MAP4K1 (0.47) | MAP4K1ACVR1FYNPIK3CAPIK3CD | |
| SCHEMBL30360601 | 0.88 | MAP4K1 (0.47) | MAP4K1ACVR1FYNPIK3CAPIK3CD | |
| SCHEMBL26516742 | 0.87 | MAP4K1 (0.40) | MAP4K1ACVR1SLC6A9PRKDCRAD52 | |
| SCHEMBL30360618 | 0.87 | PRKDC (0.37) | MAP4K1ACVR1PRKDCPTGS1PTGS2 | |
| SCHEMBL26516738 | 0.87 | PRKDC (0.37) | MAP4K1ACVR1PRKDCPTGS1PTGS2 | |
| SCHEMBL26516639 | 0.85 | ACVR1 (0.50) | MAP4K1ACVR1FYNPIK3CAPIK3CD | |
| SCHEMBL30360624 | 0.85 | ACVR1 (0.50) | MAP4K1ACVR1FYNPIK3CAPIK3CD | |
| SCHEMBL30360625 | 0.82 | HRH3 (0.41) | MAP4K1ACVR1PIK3CAMTORHRH3 | |
| SCHEMBL26516735 | 0.82 | HRH3 (0.41) | MAP4K1ACVR1PIK3CAMTORHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4200015-A1 | SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | Bristol-Myers Squibb Company (US) | 2023-06-28 | — | — | EP | claimed |
| CN-115956077-A | Substituted heteroaryl compounds as TLR9 inhibitors | 百时美施贵宝公司 | 2023-04-11 | — | — | CN | claimed |