Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | FRS2 | Q8WU20 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26516738 | 1.00 | PRKDC (0.37) | PRKDCGPR119GABRA2FGFR1MAP4K1 | |
| SCHEMBL26516667 | 0.89 | MAP4K1 (0.39) | PRKDCGPR119MAP4K1PTGS2 | |
| SCHEMBL26516732 | 0.87 | MAP4K1 (0.41) | PRKDCMAP4K1ACVR1PTGS1PTGS2 | |
| SCHEMBL30360607 | 0.87 | MAP4K1 (0.41) | PRKDCMAP4K1ACVR1PTGS1PTGS2 | |
| SCHEMBL26516742 | 0.86 | MAP4K1 (0.40) | PRKDCGPR119GABRA2MAP4K1ACVR1 | |
| SCHEMBL30360625 | 0.84 | HRH3 (0.41) | PRKDCGPR119GABRA2FGFR1MAP4K1 | |
| SCHEMBL26516735 | 0.84 | HRH3 (0.41) | PRKDCGPR119GABRA2FGFR1MAP4K1 | |
| SCHEMBL26516688 | 0.80 | MAP4K1 (0.39) | GPR119MAP4K1ACVR1PTGS1PTGS2 | |
| SCHEMBL26516685 | 0.80 | MAP4K1 (0.39) | GPR119MAP4K1ACVR1PTGS1PTGS2 | |
| SCHEMBL30360601 | 0.75 | MAP4K1 (0.47) | GPR119MAP4K1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4200015-A1 | SUBSTITUTED HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | Bristol-Myers Squibb Company (US) | 2023-06-28 | — | — | EP | claimed |
| CN-115956077-A | Substituted heteroaryl compounds as TLR9 inhibitors | 百时美施贵宝公司 | 2023-04-11 | — | — | CN | claimed |