⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636250 | 0.90 | KDM4E (0.46) | — | |
| SCHEMBL1515138 | 0.90 | — | — | |
| SCHEMBL2289470 | 0.88 | ALDH1A1 (0.45) | — | |
| SCHEMBL73853 | 0.84 | KDM4E (0.46) | — | |
| SCHEMBL6586283 | 0.84 | CYP1A2 (0.41) | — | |
| SCHEMBL5608026 | 0.79 | KDM4E (0.59) | — | |
| SCHEMBL5107835 | 0.77 | TSHR (0.55) | — | |
| SCHEMBL234027 | 0.75 | KDM4E (0.55) | — | |
| SCHEMBL28283233 | 0.75 | KDM4E (0.55) | — | |
| SCHEMBL11008658 | 0.75 | ALDH1A1 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 206 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114302884-B | Substituted pyridopyrimidinone compounds useful as T cell activators | 百时美施贵宝公司 | 2024-06-04 | — | — | CN | claimed |
| CN-117693508-A | Combination of T cell therapy and DGK inhibitors | 朱诺治疗学股份有限公司 | 2024-03-12 | — | — | CN | claimed |
| US-20230348384-A1 | Aza (Indole)-, Benzothiophene-, And Benzofuran-3-Sulfonamides | UCB PHARMA GMBH (DE) | 2023-11-02 | — | — | US | claimed |
| CN-116283712-A | (aza) indole-, benzothiophene-and benzofuran-3-sulfonamides | 优时比制药有限公司 | 2023-06-23 | — | — | CN | claimed |
| CN-110121499-B | (aza) indole-, benzothiophene-and benzofuran-3-sulfonamides | 优时比制药有限公司 | 2022-12-20 | — | — | CN | claimed |
| CN-115243721-A | Combination of DGK inhibitors and checkpoint antagonists | 百时美施贵宝公司 | 2022-10-25 | — | — | CN | claimed |
| US-11345662-B2 | Aza (indole)-, benzothiophene-, and benzofuran-3-sulfonamides | UCB PHARMA GMBH (DE) | 2022-05-31 | — | — | US | claimed |
| CN-114302884-A | Substituted pyridopyrimidinone based compounds useful as T cell activators | 百时美施贵宝公司 | 2022-04-08 | — | — | CN | claimed |
| US-20220048858-A1 | Aza (Indole)-, Benzothiophene-, And Benzofuran-3-Sulfonamides | UCB PHARMA GMBH (DE) | 2022-02-17 | — | — | US | claimed |
| US-20190053492-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS PESTICIDES | BAYER CROPSCIENCE AG (DE) | 2019-02-21 | — | — | US | claimed |
| EP-2582698-A1 | SUBSTITUTED 5-,6- AND 7-MEMBERED HETEROCYCLES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, AND THEIR USE | Vitae Pharmaceuticals, Inc. (US) | 2013-04-24 | — | — | EP | claimed |
| WO-2012119984-A1 | INDOLECARBOXAMIDES AND BENZIMIDAZOLECARBOXAMIDES AS INSECTICIDES AND ACARICIDES | BAYER CROPSCIENCE AG (DE) | 2012-09-13 | — | — | WO | claimed |
| JP-2012500812-A | — | — | 2012-01-12 | — | — | JP | claimed |
| WO-2011159760-A1 | SUBSTITUTED 5-,6- AND 7-MEMBERED HETEROCYCLES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, AND THEIR USE | VITAE PHARMACEUTICALS, INC. (US) | 2011-12-22 | — | — | WO | claimed |
| US-20110190282-A1 | NOVEL VEGF-2 RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2011-08-04 | — | — | US | claimed |
| EP-2346827-A1 | PYRIDINE DERIVATIVES AS VEGFR-2 RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-07-27 | — | — | EP | claimed |
| CN-102131782-A | Pyridine derivatives as VEGF-2 receptor and protein tyrosine kinase inhibitors | LEO PHARMA AS | 2011-07-20 | — | — | CN | claimed |
| WO-2010022725-A1 | PYRIDINE DERIVATIVES AS VEGFR-2 RECEPTOR AND PROTEIN TYROSINE KINASE INHIBITORS | LEO PHARMA A/S (DK) | 2010-03-04 | — | — | WO | claimed |
| CN-1162304-A | Imidic acid derivatives and their use as pesticides | BAYER AG (DE) | 1997-10-15 | — | — | CN | claimed |
| CN-1158605-A | N-alkoxy-amidine derivatives and their use as pesticides | BAYER AG (DE) | 1997-09-03 | — | — | CN | claimed |