Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23902746 | 1.00 | PPARG (0.54) | PPARGPLA2G2AMAPTMAPK10TP53 | |
| SCHEMBL30364951 | 0.80 | PPARG (0.60) | PPARG | |
| SCHEMBL30364672 | 0.79 | PPARG (0.45) | PPARGMAPTMAPK10TP53TAAR1 | |
| SCHEMBL23902668 | 0.79 | PPARG (0.45) | PPARGMAPTMAPK10TP53TAAR1 | |
| Hydrochloric Acid SCHEMBL19896403 | 0.78 | MAOB (0.50) | MAPTMAPK10TAAR1MAOBALDH1A1 | |
| SCHEMBL23902707 | 0.78 | ICMT (0.53) | MAPTTP53TAAR1MAOBALDH1A1 | |
| SCHEMBL30364930 | 0.78 | ICMT (0.53) | MAPTTP53TAAR1MAOBALDH1A1 | |
| SCHEMBL23902644 | 0.76 | PPARG (0.54) | PPARGMAPT | |
| SCHEMBL30241343 | 0.76 | PPARG (0.54) | PPARGMAPT | |
| SCHEMBL28942976 | 0.74 | ICMT (0.53) | MAPTMAOBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667216-B | (1H-indol-5-yl) acrylamide derivatives as inhibitors of TEAD proteins and HIPPO-YAP1/TAZ signaling cascades for the treatment of cancer | 赛诺菲 | 2025-02-18 | — | — | CN | disclosed |
| CN-115667216-A | (1H-indol-5-yl) acrylamide derivatives as TEAD proteins and inhibitors of the HIPPO-YAP1/TAZ signaling cascade for the treatment of cancer | 赛诺菲 | 2023-01-31 | — | — | CN | disclosed |