Sugi Predict

Sugi Predict / Targets / ICMT

ICMT

Protein-S-isoprenylcysteine O-methyltransferase · O60725 · ICMT on Sugi Atlas →

21,571 patent compounds predicted against ICMT, 9,362 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Cysmethynil Cysmethynil (SCHEMBL2013327) 1.00 20/20
SCHEMBL1819474 SCHEMBL1819474 0.59 16/20
SCHEMBL1819477 SCHEMBL1819477 0.59 16/20
SCHEMBL1819478 SCHEMBL1819478 0.59 16/20
SCHEMBL1816049 SCHEMBL1816049 0.58 16/20
SCHEMBL1816053 SCHEMBL1816053 0.58 16/20
SCHEMBL1816054 SCHEMBL1816054 0.58 16/20
SCHEMBL1817152 SCHEMBL1817152 0.61 15/20
SCHEMBL1817155 SCHEMBL1817155 0.61 15/20
SCHEMBL1817157 SCHEMBL1817157 0.61 15/20
SCHEMBL1819480 SCHEMBL1819480 0.54 15/20
SCHEMBL1819482 SCHEMBL1819482 0.54 15/20
SCHEMBL1819486 SCHEMBL1819486 0.54 15/20
SCHEMBL1819720 SCHEMBL1819720 0.52 15/20
SCHEMBL1819725 SCHEMBL1819725 0.52 15/20
SCHEMBL1819728 SCHEMBL1819728 0.52 15/20
SCHEMBL1304833 SCHEMBL1304833 0.68 14/20
SCHEMBL664393 SCHEMBL664393 0.67 14/20
SCHEMBL1648108 SCHEMBL1648108 0.67 14/20
SCHEMBL1648111 SCHEMBL1648111 0.67 14/20

Clinical trials — most relevant to ICMT by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood Arsenic PHASE4COMPLETED
NEO100 and High-Grade Meningioma PHASE2RECRUITING
Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma PHASE1/PHASE2RECRUITING
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor PHASE1/PHASE2NOT_YET_RECRUITING
Phase II Study of Simvastatin Plus Irinotecan, Fluorouracil, and Leucovorin(FOLFIRI) for Metastatic CRC PHASE2COMPLETED
Fosmidomycin With Clindamycin or With Clindamycin Plus Artesunate PHASE2WITHDRAWN
Simvastatin + Cetuximab/Irinotecan in K-ras Mutant Colorectal Cancer (CRC) PHASE2COMPLETED
Fosmidomycin and Azithromycin for Acute Uncomplicated Plasmodium Falciparum Malaria (P. Malaria) in Adults PHASE2UNKNOWN
Vaccine Treatment for Advanced Non-Small Cell Lung Cancer PHASE1/PHASE2COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
Impact Of Choline in Patients With NAFLD nanUNKNOWN
Human Requirements for the Nutrient Choline nanCOMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients nanCOMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels nanCOMPLETED
Treating Oxidative Stress and the Metabolic Pathology of Autism nanCOMPLETED
Dietary Effects of Sulfur Amino Acids nanCOMPLETED
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD nanNOT_YET_RECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
The Effect of Dietary Management and Cysteine Supplementation on Growth Parameters and Biochemical Control for Pediatric Qatari Patients Affected with Classical B6 Non-responsive Homocystinuria. nanNOT_YET_RECRUITING
The Safety and Efficacy Study of RiaGev in Healthy Adults nanUNKNOWN
Expression of TET1 Gene in Acute Leukaemia nanUNKNOWN
Cracking the Egg Potential: Improving Young Child Nutrition in Ecuador nanCOMPLETED
Choline to Improve Malnutrition and Enhance Cognition nanRECRUITING
S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease nanUNKNOWN
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN) nanUNKNOWN
Presence of Cyclopropane Fatty Acids (CPFA) in Human Plasma nanCOMPLETED
Holotranscobalamin Remains Unchanged During Pregnancy nanCOMPLETED
Proof of Concept Creatine Supplementation for Homocystinuria Study nanACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ICMT binder may also engage these)

ProteinNameSimilarity
Q9WVM4 — 1.000 Q9WVM4 →
Q9EQK7 — 1.000 Q9EQK7 →
O12947 — 0.990 O12947 →
D6WJ77 — 0.985 D6WJ77 →
Q5RIU9 — 0.982 Q5RIU9 →
P31214 — 0.978 P31214 →
P87014 — 0.978 P87014 →
Q99N99 — 0.977 Q99N99 →
Q5R7H4 — 0.975 Q5R7H4 →
Q28892 — 0.975 Q28892 →
P32584 — 0.975 P32584 →
Q3U9G9 — 0.974 Q3U9G9 →
O08984 — 0.974 O08984 →
A8X8R3 — 0.974 A8X8R3 →
P24008 — 0.973 P24008 →
Q4VV71 — 0.972 Q4VV71 →
Q8T8L8 — 0.972 Q8T8L8 →
Q6GNM0 — 0.972 Q6GNM0 →
Q6NYV8 — 0.972 Q6NYV8 →
Q9VEG9 — 0.972 Q9VEG9 →
Q8BML2 — 0.971 Q8BML2 →
Q9LDR4 — 0.971 Q9LDR4 →
Q1L911 — 0.971 Q1L911 →
Q49LS7 — 0.971 Q49LS7 →
Q9UKY4 — 0.970 Q9UKY4 →
Q296J9 — 0.970 Q296J9 →
LBR Delta(14)-sterol reductase LBR 0.970 landscape →
Q56A06 — 0.970 Q56A06 →
Q7L5A8 — 0.970 Q7L5A8 →
Q0P4J9 — 0.970 Q0P4J9 →