Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | GCGR | P47871 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 2/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | BCR | P11274 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23902736 | 1.00 | HTR6 (0.50) | HTR6GCGRPLAUPLGHDAC8 | |
| SCHEMBL30365128 | 0.86 | PLAU (0.51) | HTR6PLAUPLGPRKCIEPHX2 | |
| SCHEMBL3510208 | 0.86 | PLAU (0.51) | HTR6PLAUPLGPRKCIEPHX2 | |
| SCHEMBL2056298 | 0.84 | GCGR (0.48) | GCGRPLAUPLGHDAC8HDAC6 | |
| SCHEMBL15712272 | 0.83 | HDAC8 (0.60) | HTR6PLAUPLGHDAC8HDAC6 | |
| SCHEMBL31577316 | 0.82 | KCNQ3 (0.55) | HTR6PLAUPLGHDAC8HDAC6 | |
| SCHEMBL24855125 | 0.81 | NPC1 (0.50) | HTR6GCGRHDAC8HDAC6HDAC11 | |
| SCHEMBL30844613 | 0.81 | NPC1 (0.50) | HTR6GCGRHDAC8HDAC6HDAC11 | |
| SCHEMBL4939166 | 0.81 | SCN9A (0.50) | GCGRPLAUPLGHDAC8HDAC6 | |
| SCHEMBL6084878 | 0.81 | HTR6 (0.59) | HTR6GCGRPLAUHDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667216-B | (1H-indol-5-yl) acrylamide derivatives as inhibitors of TEAD proteins and HIPPO-YAP1/TAZ signaling cascades for the treatment of cancer | 赛诺菲 | 2025-02-18 | — | — | CN | disclosed |
| CN-115667216-A | (1H-indol-5-yl) acrylamide derivatives as TEAD proteins and inhibitors of the HIPPO-YAP1/TAZ signaling cascade for the treatment of cancer | 赛诺菲 | 2023-01-31 | — | — | CN | disclosed |