Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 12/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 3/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30499547 | 0.81 | BTK (0.38) | BTKMERTKCDK8CDK19 | |
| SCHEMBL30367527 | 0.81 | MERTK (0.38) | BTKMERTKTLR9TLR8CDK8 | |
| SCHEMBL30367283 | 0.80 | MERTK (0.46) | BTKMERTK | |
| SCHEMBL29052744 | 0.80 | MERTK (0.46) | BTKMERTK | |
| SCHEMBL30367399 | 0.80 | TLR9 (0.42) | BTKTLR9TLR8ROCK2 | |
| SCHEMBL30367568 | 0.75 | BTK (0.45) | BTKKDM5ATLR9TLR8CDK8 | |
| SCHEMBL2204274 | 0.73 | MAPT (0.51) | BTKCDK8CDK19SMN1; SMN2 | |
| SCHEMBL2230493 | 0.73 | BTK (0.41) | BTK | |
| SCHEMBL2201444 | 0.73 | ADORA2A (0.41) | BTKCDK8CDK19 | |
| SCHEMBL2232196 | 0.72 | KDR (0.38) | BTKCDK8CDK19ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023155886-A1 | PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS | SHANGHAI ANTENGENE CORPORATION LIMITED (CN) | 2023-08-24 | — | — | WO | disclosed |
| CN-116437918-A | Pyrazolopyridine compounds as TAM inhibitors | 上海德琪医药科技有限公司 | 2023-07-14 | — | — | CN | disclosed |
| WO-2023051464-A1 | PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS | SHANGHAI ANTENGENE CORPORATION LIMITED (CN) | 2023-04-06 | — | — | WO | disclosed |