SCHEMBL30367312

SCHEMBL30367312

CC(C)C(=O)N1CCC(c2cc(-c3ccc(NC(=O)c4cncc(-c5ccc(F)cc5)c4O)cc3)c3c(N)nccn23)CC1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MERTK Q12866 12/20 0.56
TYRO3 Q06418 10/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30367383 0.84 MERTK (0.46) MERTKTYRO3
SCHEMBL30499527 0.81 BTK (0.44) MERTKTYRO3
SCHEMBL30367439 0.79 BTK (0.50) MERTKTYRO3
SCHEMBL30367487 0.78 MERTK (0.43) MERTKTYRO3
SCHEMBL29052477 0.78 MERTK (0.43) MERTKTYRO3
SCHEMBL29052441 0.78 MERTK (0.46) MERTKTYRO3
SCHEMBL29052756 0.78 MERTK (0.46) MERTKTYRO3
SCHEMBL29052744 0.78 MERTK (0.46) MERTKTYRO3
SCHEMBL30367283 0.78 MERTK (0.46) MERTKTYRO3
SCHEMBL30367688 0.78 MERTK (0.46) MERTKTYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116437918-A Pyrazolopyridine compounds as TAM inhibitors 上海德琪医药科技有限公司 2023-07-14 CN disclosed
WO-2023051464-A1 PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS SHANGHAI ANTENGENE CORPORATION LIMITED (CN) 2023-04-06 WO disclosed