SCHEMBL30367510

SCHEMBL30367510

COc1ccc(CNc2nccc3c2c(-c2ccc(N)cc2F)nn3C2CCN(C(=O)C(C)C)CC2)c(OC)c1

nearest known ligand 0.41

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ BTK Q06187 17/20 0.41
▸ DPP7 Q9UHL4 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ TYRO3 Q06418 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30499571 0.90 EGFR (0.40) BTKDPP7KMT2A
SCHEMBL30367690 0.84 KMT2A (0.41) BTKDPP7KMT2A
SCHEMBL30499566 0.81 TYRO3 (0.35) BTKTYRO3
SCHEMBL29998362 0.77 EGFR (0.41) BTKKMT2A
SCHEMBL24096504 0.77 EGFR (0.41) BTKKMT2A
SCHEMBL21903861 0.74 BTK (0.43) BTK
SCHEMBL21903865 0.74 BTK (0.43) BTK
SCHEMBL21903524 0.74 EPHX2 (0.44) BTKKMT2A
SCHEMBL24096641 0.73 TP53 (0.41) KMT2A
SCHEMBL29998774 0.73 TP53 (0.41) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116437918-A Pyrazolopyridine compounds as TAM inhibitors 上海德琪医药科技有限公司 2023-07-14 — — CN disclosed
WO-2023051464-A1 PYRAZOLOPYRIDINE COMPOUNDS AS TAM INHIBITORS SHANGHAI ANTENGENE CORPORATION LIMITED (CN) 2023-04-06 — — WO disclosed
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