Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL617400 | 0.84 | KEAP1 (0.69) | KEAP1ALDH1A1MAPTHPGDSHMT2 | |
| Hydrochloric Acid SCHEMBL9097278 | 0.83 | KEAP1 (0.53) | KEAP1ALDH1A1MAPTHPGDSHMT2 | |
| SCHEMBL10531939 | 0.83 | KEAP1 (0.52) | KEAP1ALDH1A1MAPTHPGDSHMT2 | |
| SCHEMBL8355750 | 0.82 | MAOB (0.56) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL10533354 | 0.82 | MAPT (0.49) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL617539 | 0.81 | MAPT (0.63) | KEAP1ALDH1A1MAPTHPGDSHMT2 | |
| SCHEMBL10829908 | 0.80 | MEN1 (0.61) | KEAP1ALDH1A1MAPTHPGDSHMT2 | |
| SCHEMBL8357492 | 0.79 | MAPT (0.62) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL14676613 | 0.79 | MAOB (0.52) | ALDH1A1MAPTHPGDSHMT2MEN1 | |
| SCHEMBL15501213 | 0.78 | CYP1A2 (0.71) | ALDH1A1HPGDMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220177928-A1 | PRODUCTION OF SQUALENE FROM HYPER-PRODUCING YEASTS | NOVARTIS AG (CH) | 2022-06-09 | — | — | US | claimed |
| US-11236366-B2 | Production of squalene from hyper-producing yeasts | NOVARTIS AG (CH) | 2022-02-01 | — | — | US | claimed |
| EP-2369003-B1 | PROCESS FOR PREPARING AN OIL-IN-WATER EMULSION CONTAINING SQUALENE FROM YEASTS | NOVARTIS AG (CH) | 2019-10-16 | — | — | EP | claimed |
| JP-2012500648-A | — | — | 2012-01-12 | — | — | JP | claimed |
| US-20110243969-A1 | PRODUCTION OF SQUALENE FROM HYPER-PRODUCING YEASTS | NOVARTIS AG | 2011-10-06 | — | — | US | claimed |
| EP-2369003-A1 | Production of squalene from hyper-producing yeasts | Novartis AG (CH) | 2011-09-28 | — | — | EP | claimed |
| EP-2268823-B1 | PRODUCTION OF SQUALENE FROM HYPER-PRODUCING YEASTS | NOVARTIS AG (CH) | 2011-06-22 | — | — | EP | claimed |
| EP-2268823-A2 | PRODUCTION OF SQUALENE FROM HYPER-PRODUCING YEASTS | Broeker, Michael (DE) | 2011-01-05 | — | — | EP | claimed |
| WO-2010023551-A2 | PRODUCTION OF SQUALENE FROM HYPER-PRODUCING YEASTS | BROEKER MICHAEL (DE) | 2010-03-04 | — | — | WO | claimed |
| WO-2002051393-A2 | PROCESS TO INCREASE THE CONCENTRATION OF MEIOSIS-ACTIVATING STEROLS (MAS) IN THE CHOLESTEROL SYNTHESIS AND THE USE OF POTENT INHIBITORS IN THE PROCESS | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | claimed |
| EP-1216701-A1 | Process to increase the concentration of meiosis-activating sterols (MAS) in the cholesterol synthesis and the use of potent inhibitors in the process | Schering Aktiengesellschaft (DE) | 2002-06-26 | — | — | EP | claimed |
| CN-115463687-A | Benzotrithiophene covalent organic framework catalyst and preparation method and application thereof | 湖南大学 | 2022-12-13 | — | — | CN | disclosed |
| US-20220177928-A1 | PRODUCTION OF SQUALENE FROM HYPER-PRODUCING YEASTS | NOVARTIS AG (CH) | 2022-06-09 | — | — | US | disclosed |
| US-11236366-B2 | Production of squalene from hyper-producing yeasts | NOVARTIS AG (CH) | 2022-02-01 | — | — | US | disclosed |
| CN-105431542-B | Production of squalene and/or sterol from cell suspensions of fermented yeast | 赛诺菲-安万特德国有限公司 | 2020-04-07 | — | — | CN | disclosed |
| WO-2014139989-A1 | PRODUCTION OF SQUALENE AND/OR STEROL FROM CELL SUSPENSIONS OF FERMENTED YEAST | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2014-09-18 | — | — | WO | disclosed |
| WO-2002051393-A2 | PROCESS TO INCREASE THE CONCENTRATION OF MEIOSIS-ACTIVATING STEROLS (MAS) IN THE CHOLESTEROL SYNTHESIS AND THE USE OF POTENT INHIBITORS IN THE PROCESS | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-07-04 | — | — | WO | disclosed |
| EP-1216701-A1 | Process to increase the concentration of meiosis-activating sterols (MAS) in the cholesterol synthesis and the use of potent inhibitors in the process | Schering Aktiengesellschaft (DE) | 2002-06-26 | — | — | EP | disclosed |
| EP-0813595-A1 | STIMULATION OF MEIOSIS | NOVO NORDISK A/S (DK) | 1997-12-29 | — | — | EP | disclosed |
| WO-1996027658-A1 | STIMULATION OF MEIOSIS | NOVO NORDISK A/S (DK) | 1996-09-12 | — | — | WO | disclosed |