Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25304282 | 0.89 | HDAC1 (0.47) | HDAC1HDAC6RORCGRIN2BGRIN1 | |
| SCHEMBL30474059 | 0.88 | HDAC1 (0.44) | HDAC1HDAC6RORCGRIN2BGRIN1 | |
| SCHEMBL24073258 | 0.88 | HDAC1 (0.44) | HDAC1HDAC6RORCGRIN2BGRIN1 | |
| SCHEMBL24073263 | 0.88 | HDAC1 (0.46) | HDAC1HDAC6RORCGRIN2BGRIN1 | |
| SCHEMBL30370531 | 0.88 | HDAC1 (0.46) | HDAC1HDAC6RORCGRIN2BGRIN1 | |
| SCHEMBL25260376 | 0.88 | HDAC1 (0.46) | HDAC1HDAC6RORCGRIN2BGRIN1 | |
| SCHEMBL31017693 | 0.83 | HDAC1 (0.48) | HDAC1HDAC6RORCGRIN2BGRIN1 | |
| SCHEMBL24073262 | 0.83 | HDAC1 (0.48) | HDAC1HDAC6RORCGRIN2BGRIN1 | |
| Trifluoroacetic Acid SCHEMBL30371030 | 0.80 | HDAC1 (0.46) | HDAC1HDAC6GRIN2BGRIN1CYP2C19 | |
| SCHEMBL25248803 | 0.79 | HDAC1 (0.47) | HDAC1HDAC6RORCGRIN2BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157834-A1 | N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION | Mission Therapeutics Limited (GB) | 2023-04-05 | — | — | EP | disclosed |