Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.49 |
| ▸ | CTSK | P43235 | 3/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 5/20 | 0.43 |
| ▸ | PPARG | P37231 | 4/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23886587 | 1.00 | CTSS (0.49) | CTSSCTSKPTPN1S1PR3PPARA | |
| SCHEMBL8511514 | 1.00 | CTSS (0.49) | CTSSCTSKPTPN1S1PR3PPARA | |
| SCHEMBL16334202 | 1.00 | CTSS (0.49) | CTSSCTSKPTPN1S1PR3PPARA | |
| SCHEMBL29571369 | 1.00 | CTSS (0.49) | CTSSCTSKPTPN1S1PR3PPARA | |
| SCHEMBL30370648 | 1.00 | CTSS (0.49) | CTSSCTSKPTPN1S1PR3PPARA | |
| SCHEMBL3447506 | 0.89 | CTSS (0.44) | CTSSCTSKPTPN1S1PR3PPARA | |
| SCHEMBL15269846 | 0.87 | CTSS (0.45) | CTSSCTSKPTPN1S1PR3ATM | |
| SCHEMBL15670451 | 0.87 | CTSS (0.45) | CTSSCTSKPTPN1S1PR3ATM | |
| SCHEMBL31444364 | 0.87 | S1PR3 (0.43) | CTSSCTSKPTPN1S1PR3PPARA | |
| SCHEMBL6120380 | 0.85 | MEN1 (0.47) | ATMGAACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126876-A1 | PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | Global Blood Therapeutics, Inc. (US) | 2023-02-08 | — | — | EP | disclosed |