Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.55 |
| ▸ | PPARA | Q07869 | 14/20 | 0.53 |
| ▸ | PPARD | Q03181 | 5/20 | 0.51 |
| ▸ | PPARG | P37231 | 4/20 | 0.51 |
| ▸ | CFTR | P13569 | 1/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.49 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.49 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24073620 | 1.00 | CTSD (0.55) | CTSDPPARAPPARDPPARGCFTR | |
| SCHEMBL8116932 | 0.83 | MAPT (0.47) | PPARAPPARDPPARGCFTRSCN8A | |
| SCHEMBL29617695 | 0.83 | CFTR (0.50) | PPARACFTRSCN8ASCN10AMAPT | |
| SCHEMBL4638408 | 0.83 | CFTR (0.50) | PPARACFTRSCN8ASCN10AMAPT | |
| SCHEMBL344681 | 0.83 | MAPT (0.48) | PPARAPPARDPPARGCFTRSCN8A | |
| SCHEMBL4070406 | 0.83 | CFTR (0.62) | PPARAPPARDPPARGCFTRSCN8A | |
| SCHEMBL10712777 | 0.82 | PPARA (0.54) | PPARAPPARDPPARGPSEN1PSEN2 | |
| SCHEMBL24801415 | 0.82 | PPARA (0.57) | PPARAPPARDPPARGPSEN1PSEN2 | |
| Hydrochloric Acid SCHEMBL8102752 | 0.82 | MAPT (0.46) | PPARAPPARDPPARGCFTRSCN8A | |
| SCHEMBL320173 | 0.81 | CYP2C19 (0.50) | PPARACFTRSCN8ASCN10AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157834-A1 | N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION | Mission Therapeutics Limited (GB) | 2023-04-05 | — | — | EP | disclosed |