Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GRK2 | P25098 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25180540 | 1.00 | ROCK2 (0.51) | ROCK2NPC1RAB9AKMT2AGRK2 | |
| SCHEMBL30375530 | 0.87 | ROCK2 (0.51) | ROCK2NPC1RAB9AKMT2AGRK2 | |
| SCHEMBL25191066 | 0.87 | ROCK2 (0.51) | ROCK2NPC1RAB9AKMT2AGRK2 | |
| SCHEMBL29276417 | 0.84 | ROCK2 (0.50) | ROCK2NPC1RAB9AKMT2AGRK2 | |
| SCHEMBL20786971 | 0.80 | TDP1 (0.55) | ROCK2NPC1RAB9AKMT2ATDP1 | |
| SCHEMBL25173805 | 0.80 | ROCK2 (0.53) | ROCK2GRK2AURKAROCK1RPS6KA1 | |
| SCHEMBL25179853 | 0.79 | ROCK2 (0.45) | ROCK2GRK2AURKAROCK1RPS6KA1 | |
| SCHEMBL30374973 | 0.79 | ROCK2 (0.45) | ROCK2GRK2AURKAROCK1RPS6KA1 | |
| SCHEMBL25198907 | 0.77 | ROCK2 (0.44) | ROCK2NPC1RAB9AKMT2AGRK2 | |
| SCHEMBL30375364 | 0.77 | ROCK2 (0.44) | ROCK2NPC1RAB9AKMT2AGRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426681-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | Sitryx Therapeutics Limited (GB) | 2024-09-11 | — | — | EP | disclosed |
| CN-118317951-A | Phthalazine derivatives as pyruvate kinase modulators | 西特瑞治疗有限公司 | 2024-07-09 | — | — | CN | disclosed |
| WO-2023079294-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |