Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 6/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 6/20 | 0.50 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | GRAMD1A | Q96CP6 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25181330 | 1.00 | DDB1 (0.50) | DDB1CRBNBCHECNR2PDK2 | |
| SCHEMBL22276609 | 0.84 | CRBN (0.70) | DDB1CRBNSTAT3MAPTGRAMD1A | |
| SCHEMBL23729668 | 0.79 | CRBN (0.75) | DDB1CRBNPDK2STAT3 | |
| SCHEMBL29648331 | 0.77 | CRBN (0.47) | DDB1CRBNBCHECNR2PDK2 | |
| SCHEMBL24501909 | 0.77 | CRBN (0.47) | DDB1CRBNBCHECNR2PDK2 | |
| SCHEMBL25182446 | 0.77 | CRBN (0.49) | DDB1CRBN | |
| SCHEMBL5958855 | 0.77 | CRBN (0.42) | DDB1CRBNCA12CA1CA9 | |
| SCHEMBL30375858 | 0.77 | CRBN (0.49) | DDB1CRBN | |
| SCHEMBL30378743 | 0.76 | CRBN (0.48) | DDB1CRBN | |
| SCHEMBL30831063 | 0.76 | CRBN (0.48) | DDB1CRBNMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426700-A1 | HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS | Merck Patent GmbH (DE) | 2024-09-11 | — | — | EP | disclosed |
| WO-2023078813-A1 | HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS | MERCK PATENT GMBH (DE) | 2023-05-11 | — | — | WO | disclosed |