Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | RXRB | P28702 | 1/20 | 0.55 |
| ▸ | RXRG | P48443 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 5/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 5/20 | 0.38 |
| ▸ | ATR | Q13535 | 7/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139239 | 1.00 | RXRA (0.55) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL2471554 | 0.90 | RXRA (0.64) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL24900268 | 0.88 | RXRA (0.58) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL17039301 | 0.88 | RXRA (0.55) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL7132596 | 0.88 | RXRA (0.55) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL22912884 | 0.84 | RXRA (0.73) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL2144301 | 0.83 | RXRA (0.50) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL29756229 | 0.83 | RXRA (0.50) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL17034421 | 0.81 | RXRA (0.50) | RXRARXRBRXRGALDH1A1LMNA | |
| SCHEMBL21786656 | 0.81 | RXRA (0.50) | RXRARXRBRXRGALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426681-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | Sitryx Therapeutics Limited (GB) | 2024-09-11 | — | — | EP | disclosed |
| WO-2023079294-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |