Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 16/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 16/20 | 0.56 |
| ▸ | WNT1 | P04628 | 11/20 | 0.56 |
| ▸ | CLK2 | P49760 | 1/20 | 0.53 |
| ▸ | CLK3 | P49761 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | PI4KA | P42356 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20945222 | 1.00 | GSK3B (0.56) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL25424298 | 0.94 | ABL1 (0.56) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL30695432 | 0.90 | GSK3B (0.47) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL20916079 | 0.87 | GSK3B (0.50) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL10165956 | 0.85 | PDPK1 (0.43) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL25646429 | 0.83 | GSK3B (0.57) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL15507418 | 0.82 | GSK3B (0.56) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL30481240 | 0.82 | GSK3B (0.56) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL25603068 | 0.82 | GSK3B (0.56) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL30695495 | 0.80 | PIK3CD (0.55) | GSK3BDYRK1AWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118843626-A | Heterocyclic compounds as DYRK1A inhibitors | 普罗塞纳生物科学有限公司 | 2024-10-25 | — | — | CN | disclosed |
| EP-4444420-A2 | CYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Prothena Biosciences Limited (IE) | 2024-10-16 | — | — | EP | disclosed |
| CN-117209469-A | Compounds as CLK inhibitors and uses thereof | 南京圣和药物研发有限公司 | 2023-12-12 | — | — | CN | disclosed |
| WO-2023107723-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |