SCHEMBL30383735

SCHEMBL30383735

CSc1ccc(C(=O)C=Cc2ccc(O)c(C(F)(F)F)c2)cc1

nearest known ligand 0.72

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.61
▸ MEN1 O00255 2/20 0.61
▸ ALDH1A1 P00352 2/20 0.61
▸ LMNA P02545 2/20 0.61
▸ RAB9A P51151 2/20 0.61
▸ KMT2A Q03164 2/20 0.61
▸ GAA P10253 1/20 0.61
▸ CASP3 P42574 1/20 0.61
▸ SENP8 Q96LD8 1/20 0.61
▸ SENP7 Q9BQF6 1/20 0.61
▸ SENP6 Q9GZR1 1/20 0.61
▸ P4HB P07237 4/20 0.57
▸ NPC1 O15118 1/20 0.56
▸ NFKB1 P19838 1/20 0.56
▸ HTT P42858 1/20 0.56
▸ NFKB2 Q00653 1/20 0.56
▸ RELA Q04206 1/20 0.56
▸ SMN1; SMN2 Q16637 1/20 0.56
▸ CXCL12 P48061 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30383574 1.00 MAPT (0.61) MAPTMEN1ALDH1A1LMNARAB9A
SCHEMBL3969205 1.00 MAPT (0.61) MAPTMEN1ALDH1A1LMNARAB9A
SCHEMBL3969203 1.00 MAPT (0.61) MAPTMEN1ALDH1A1LMNARAB9A
SCHEMBL9341891 0.84 MAPT (0.71) MAPTMEN1ALDH1A1LMNARAB9A
SCHEMBL30039604 0.84 MAPT (0.71) MAPTMEN1ALDH1A1LMNARAB9A
SCHEMBL9341898 0.84 MAPT (0.71) MAPTMEN1ALDH1A1LMNARAB9A
SCHEMBL4461037 0.83 MAPT (0.66) MAPTMEN1ALDH1A1LMNARAB9A
SCHEMBL4461040 0.83 MAPT (0.66) MAPTMEN1ALDH1A1LMNARAB9A
SCHEMBL28600841 0.82 MAPT (0.68) MAPTMEN1ALDH1A1LMNARAB9A
SCHEMBL25195919 0.81 PPARG (0.64) MAPTMEN1ALDH1A1LMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 — — WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 — — EP disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 — — WO disclosed
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